Memory performance in ADC/NACC data

 
   Lead Investigator:    Sandra Barral Rodriguez
   Institution      :    Columbia
   E-Mail           :    smb2174@cumc.columbia.edu
   Proposal ID      :    317


   Publications:


1  Barral S, Cosentino S, Christensen K, Newman AB, Perls TT, Province MA, Mayeux R
   Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly
   Journal Article  JAMA Neurol,71:1514-1519,2014,PMC4355405

   PUBLISHED



2  Barral S, Reitz C, Small SA, Mayeux R
   Genetic variants in a 'cAMP element binding protein' (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals
   Journal Article  Neurobiol Aging,35:e2887-2881 e281,2014,PMC4253058

   PUBLISHED



3  Lee S,  Zhou X , Vardarajan B, Reyes-Dumeyer D, Rajan KB, Wilson RS, Evans DA,  Besser L, Kukull W,  Bennett DA, Schupf N, Mayeux R, Barral S
   Episodic Memory Performance in a Multiethnic Longitudinal Study of 13,979 Elderly
   Journal Article  PLoS One,13:e0206803,2018,PMC6248922

   PUBLISHED





   Proposal Description:
   We hypothesize that genetic factors will be responsible for the individual differences in memory performance observed in non-demented individuals at the highest end of the memory ability distribution. We aim to further replicate and extend our preliminary results, the association between the SNPs on chromosome 6 and memory performance using the ADC and NACC non-demented participants that have genome-wide data available.